Evolution of the O alleles of the human ABO blood group gene.

doi:10.1111/j.1537-2995.2004.03346.x

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Article

Evolution of the O alleles of the human ABO blood group gene.

Transfusion - 1 May 2004

Roubinet Francis, Despiau Stéphanie, Calafell Francesc, Jin Fen, Bertranpetit Jaume, Saitou Naruya, Blancher Antoine, Bertanpetit Jaume

Abstract excerpt

BACKGROUND: To date, at least 40 different alleles O have been characterized on the basis of exon 6 and exon 7 sequences but not always for intron 6. STUDY DESIGN AND METHODS: Among 415 individuals, from four continents (Africa, Europe, South America, and Asia), studied for exon 6 and exon 7 sequences, we selected 46 individuals (of respective phenotypes O [39], AB [3], B [3], or A [1]) for sequencing 1800-bp...

Topics

ABO Blood-Group System
Alleles
Base Sequence
Humans
Molecular Sequence Data
Phylogeny
Recombination, Genetic

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Open in PubMed

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PMID: 15104652
DOI: 10.1111/j.1537-2995.2004.03346.x

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