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Article

Role of cAMP in phenotypic changes of osteoblasts.

Biochemical and biophysical research communications - 1 Jan 2018

Nishihara Syun, Ikeda Mami, Ozawa Hitoshi, Akiyama Masako, Yamaguchi Satoshi, Nakahama Ken-Ichi

Abstract excerpt

Bone remodeling is precisely controlled by bone formation and bone resorption, and osteoblasts are responsible for both processes. Osteoblasts exhibit an osteoclastogenic phenotype in response to elevated intracellular cyclic AMP [cAMP]i levels. However, the role of cAMP in osteoblasts acquiring an osteogenic phenotype is controversial. To elucidate the effect of cAMP on both phenotypes, an osteoblast-like cell...

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Identifiers

PMID: 29170126
DOI: 10.1016/j.bbrc.2017.11.125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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