Genomic characterization of Leishmania (V.) braziliensis associated with antimony therapeutic failure and variable in vitro tolerance to amphotericin B

Abstract excerpt

Leishmaniasis, a vector-borne disease caused by protozoa from the Leishmania genus, presents a wide range of clinical manifestations in humans and varying responses to treatments. The main clinical presentations correspond with visceral leishmaniasis (VL), cutaneous leishmaniasis (CL), and mucosal leishmaniasis (ML). Amphotericin B (AmB) is a second-line therapeutic option in all forms of leishmaniasis with...

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