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Article

Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil.

eLife - 19 Feb 2021

Snoberger Aaron, Barua Bipasha, Atherton Jennifer L, Shuman Henry, Forgacs Eva, Goldman Yale E, Winkelmann Donald A, Ostap E Michael

Abstract excerpt

Hypertrophic cardiomyopathies (HCMs) are the leading cause of acute cardiac failure in young individuals. Over 300 mutations throughout β-cardiac myosin, including in the motor domain, are associated with HCM. A β-cardiac myosin motor mutation (R712L) leads to a severe form of HCM. Actin-gliding motility of R712L-myosin is inhibited, despite near-normal ATPase kinetics. By optical trapping, the working stroke of...

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Identifiers

PMID: 33605878
DOI: 10.7554/eLife.63691
PMCID: PMC7895523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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