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Article

Performance of KRAS mutation detection in plasma exosomes from patients with early-stage colorectal cancer.

Journal of translational medicine - 2 Jul 2025

Nouri Mehraneh, Sharif Samaneh, Soltani Ehsan, Mozaffari-Jovin Sina, Abbaszadegan Mohammad Reza

Abstract excerpt

BACKGROUND: Liquid biopsy is a minimally invasive method, which is an alternative to tissue biopsy in solid cancers to detect driver mutations, monitor treatment responses, and estimate prognosis. Exosomes are a group of extracellular vesicles that are detected in body fluids and are more stable than cell-free DNA and circulating tumor cells. Genetic data of parental cells can be packaged into exosomes, analysis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40605047
DOI: 10.1186/s12967-025-06710-0
PMCID: PMC12224825

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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