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Article

Evaluation of combined detection of multigene mutation and SDC2/SFRP2 methylation in stool specimens for colorectal cancer early diagnosis.

International journal of colorectal disease - 1 Jun 2022

Lin Jie, Zhang Lijing, Chen Mengshi, Chen Juan, Wu Yijuan, Wang Tao, Lu Yan, Ba Zhaofen, Cheng Xiaowei, Xu Rongrong, Tian Tian, Sun Aijuan, Zhang Tiantian, Chen Minghong

Abstract excerpt

PURPOSE: Molecular diagnostics of colorectal cancer (CRC) can be used as an auxiliary approach for patients recommended for colonoscopy, providing more CRC supplemental diagnosis options. This study investigated whether combined detection of KRAS/BRAF/APC mutation and SDC2/SFRP2 methylation can serve as auxiliary diagnostics in clinical management. METHODS: KRAS/BRAF/APC mutation and SDC2/SFRP2 methylation in...

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PMID: 35499710
DOI: 10.1007/s00384-022-04170-2

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