Article
Interleukin-17 receptor polymorphism predisposes to primary graft dysfunction after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Jul 2015
Somers Jana, Ruttens David, Verleden Stijn E, Vandermeulen Elly, Piloni Davide, Wauters Els, Lambrechts Diether, Vos Robin, Verleden Geert M, Vanaudenaerde Bart, van Raemdonck Dirk E
Abstract excerpt
BACKGROUND: Primary graft dysfunction (PGD), with an incidence of 11% to 57%, is a major cause of morbidity and mortality within the first 30 days after lung transplantation (LTx). In this study, we postulate that recipient genetic variants in interleukin-17 and -23 receptor genes (IL-17R and IL-23R, respectively) may predispose LTx recipients to an increased risk for developing PGD. METHODS: Seven genetic...
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