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Donor Club Cell Secretory Protein G38A Polymorphism Is Associated With a Decreased Risk of Primary Graft Dysfunction in the French Cohort in Lung Transplantation.

Transplantation - 1 Aug 2018

Hin Angela, Kannengiesser Caroline, Roussel Arnaud, Renaud-Picard Benjamin, Roux Antoine, Reynaud-Gaubert Martine, Claustre Johanna, Tissot Adrien, Guillemain Romain, Mornex Jean-François, Mussot Sacha, Dromer Claire, Dahan Marcel, Brugière Olivier, Mercier Olaf, Borie Raphaël, Pretolani Marina, Castier Yves, Mordant Pierre

Abstract excerpt

BACKGROUND: Club Cell Secretory Protein (CCSP) G38A polymorphism has recently been involved in lung epithelial susceptibility to external injuries. Lung transplantation (LT) is currently limited by ischemia-reperfusion injury leading to primary graft dysfunction (PGD). We thus hypothesized that donor CCSP G38A polymorphism might impact the risk of PGD after LT. METHODS: We focused on LT included in the French...

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PMID: 29470356
DOI: 10.1097/TP.0000000000002143

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PGD

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