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Article

Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia.

Blood - 6 Mar 2014

Rotunno Giada, Mannarelli Carmela, Guglielmelli Paola, Pacilli Annalisa, Pancrazzi Alessandro, Pieri Lisa, Fanelli Tiziana, Bosi Alberto, Vannucchi Alessandro M

Abstract excerpt

Mutations in the calreticulin (CALR) gene were recently discovered in patients with essential thrombocythemia (ET) lacking the JAK2V617F and MPLW515 mutations, but no information is available on the clinical correlates. In this series, CALR mutations were found in 15.5% of 576 World Health Organization-defined ET patients, accounting for 48.9% of JAK2 and MPL wild-type (wt) patients. CALR-mutated patients were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24371211
DOI: 10.1182/blood-2013-11-538983

Genes

CALR
JAK2
MPL

Provenance

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Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia.PMID 24371211Read ↗

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Calreticulin variant stratified driver mutational status and prognosis in essential thrombocythemia.Semantic proximity Read ↗

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