Article
Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection.
Genes and immunity - 1 Jan 2000
Ampuero J, del Campo J A, Rojas L, García-Lozano R J, Buti M, Solá R, Forns X, Moreno-Otero R, Andrade R, Diago M, Salmerón J, Rodrigo L, Pons J A, Navarro J M, Calleja J L, García-Samaniego J, García-Valdecasas M, Rojas Á, Millán R, González-Escribano M F, Romero-Gómez M
Abstract excerpt
Host-viral genetic interaction has a key role in hepatitis C infection (HCV) and maybe in the viral selection. In a preliminary GWAS analysis, we identified BTN3A2 rs9104 to be associated with HCV genotype 1. Therefore, our aim was to determine the influence of BTN family on the selection of HCV genotype. We performed a fine-mapping analysis of BTN gene region in a cohort of chronic HCV infection (N=841),...
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