Article
Identification of deleterious recessive haplotypes and candidate deleterious recessive mutations in Japanese Black cattle.
Scientific reports - 23 Mar 2021
Sasaki Shinji, Watanabe Toshio, Ibi Takayuki, Hasegawa Kiyotoshi, Sakamoto Yoichi, Moriwaki Shunsuke, Kurogi Kazuhito, Ogino Atsushi, Yasumori Takanori, Wakaguri Hiroyuki, Muraki Eiji, Miki Youko, Yoshida Yuichi, Inoue Yoshinobu, Tabuchi Ichiro, Iwao Ken, Arishima Taichi, Kawashima Keisuke, Watanabe Manabu, Sugano Sumio, Sugimoto Yoshikazu, Suzuki Yutaka
Abstract excerpt
Intensive use of a few elite sires has increased the risk of the manifestation of deleterious recessive traits in cattle. Substantial genotyping data gathered using single-nucleotide polymorphism (SNP) arrays have identified the haplotypes with homozygous deficiency, which may compromise survival. We developed Japanese Black cattle haplotypes (JBHs) using SNP array data (4843 individuals) and identified...
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