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Article

Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices

1 Jan 2015

Abstract excerpt

Numerous types of cancer cells migrate into extracellular tissues. This phenomenon is termed invasion, and is associated with poor prognosis in cancer patients. In this study, we demonstrated that filamin B (FLNb), an actin-binding protein, is highly expressed in cancer cell lines that exhibit high invasiveness, with a spindle morphology, into 3D collagen matrices. In addition, we determined that knockdown of...

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PMID: 25925610
DOI: 10.1247/csf.15001

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