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Article

Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos.

Science (New York, N.Y.) - 25 Nov 2011

Sato Miyuki, Sato Ken

Abstract excerpt

The mitochondrial genome is believed to be maternally inherited in many eukaryotes. Sperm-derived paternal mitochondria enter the oocyte cytoplasm upon fertilization and then normally disappear during early embryogenesis. However, the mechanism responsible for this clearance has been unknown. Here, we show that autophagy, which delivers cytosolic components to lysosomes for degradation, is required for the...

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PMID: 21998252
DOI: 10.1126/science.1210333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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