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Article

Capturing Invisible Motions in the Transition from Ground to Rare Excited States of T4 Lysozyme L99A.

Biophysical journal - 18 Oct 2016

Schiffer Jamie M, Feher Victoria A, Malmstrom Robert D, Sida Roxana, Amaro Rommie E

Abstract excerpt

Proteins commonly sample a number of conformational states to carry out their biological function, often requiring transitions from the ground state to higher-energy states. Characterizing the mechanisms that guide these transitions at the atomic level promises to impact our understanding of functional protein dynamics and energy landscapes. The leucine-99-to-alanine (L99A) mutant of T4 lysozyme is a model system...

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Identifiers

PMID: 27760351
DOI: 10.1016/j.bpj.2016.08.041
PMCID: PMC5071553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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