Article
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant.
Nature - 21 Aug 2011
Bouvignies Guillaume, Vallurupalli Pramodh, Hansen D Flemming, Correia Bruno E, Lange Oliver, Bah Alaji, Vernon Robert M, Dahlquist Frederick W, Baker David, Kay Lewis E
Abstract excerpt
Proteins are inherently plastic molecules, whose function often critically depends on excursions between different molecular conformations (conformers). However, a rigorous understanding of the relation between a protein's structure, dynamics and function remains elusive. This is because many of the conformers on its energy landscape are only transiently formed and marginally populated (less than a few per cent...
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