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Article

Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure.

Journal of the American Society of Nephrology : JASN - 1 Dec 2015

Tomaszewski Maciej, Eales James, Denniff Matthew, Myers Stephen, Chew Guat Siew, Nelson Christopher P, Christofidou Paraskevi, Desai Aishwarya, Büsst Cara, Wojnar Lukasz, Musialik Katarzyna, Jozwiak Jacek, Debiec Radoslaw, Dominiczak Anna F, Navis Gerjan, van Gilst Wiek H, van der Harst Pim, Samani Nilesh J, Harrap Stephen, Bogdanski Pawel, Zukowska-Szczechowska Ewa, Charchar Fadi J

Abstract excerpt

The fibroblast growth factor 1 (FGF1) gene is expressed primarily in the kidney and may contribute to hypertension. However, the biologic mechanisms underlying the association between FGF1 and BP regulation remain unknown. We report that the major allele of FGF1 single nucleotide polymorphism rs152524 was associated in a dose-dependent manner with systolic BP (P = 9.65 × 10(-5)) and diastolic BP (P = 7.61 ×...

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Source

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Identifiers

PMID: 25918036
DOI: 10.1681/ASN.2014121211
PMCID: PMC4657842

Genes

FGF1
MME
PTPRO
REN
WNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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