Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.

PloS one - 1 Jan 2015

Moilanen Anne-Mari, Rysä Jaana, Kaikkonen Leena, Karvonen Teemu, Mustonen Erja, Serpi Raisa, Szabó Zoltán, Tenhunen Olli, Bagyura Zsolt, Näpänkangas Juha, Ohukainen Pauli, Tavi Pasi, Kerkelä Risto, Leósdóttir Margrét, Wahlstrand Björn, Hedner Thomas, Melander Olle, Ruskoaho Heikki

Abstract excerpt

AIMS: In a recent genome-wide association study, WD-repeat domain 12 (WDR12) was associated with early-onset myocardial infarction (MI). However, the function of WDR12 in the heart is unknown. METHODS AND RESULTS: We characterized cardiac expression of WDR12, used adenovirus-mediated WDR12 gene delivery to examine effects of WDR12 on left ventricular (LV) remodeling, and analyzed relationship between MI...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heart Failure
Share to Hemodynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HSP27 Heat-Shock Proteins

Share to Myocardial Infarction

Share to Myocytes, Cardiac

Share to p38 Mitogen-Activated Protein Kinases

Share to Rats, Sprague-Dawley

Share to RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25915632
DOI: 10.1371/journal.pone.0124907
PMCID: PMC4411154

Genes

BOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.PMID 25915632Read ↗

WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferationSemantic proximity Read ↗

Neddylation Regulates Mitochondrial Dynamics and Turnover in the Adult HeartSemantic proximity Read ↗

RNA-Binding Proteins in CardiomyopathiesSemantic proximity Read ↗

Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarctionSemantic proximity Read ↗

Abundant and Altered Expression of PIWI-Interacting RNAs during Cardiac HypertrophySemantic proximity Read ↗

Basic biology and roles of CEBPD in cardiovascular diseaseSemantic proximity Read ↗

Loss of function of the nuclear envelope protein LEMD2 causes DNA damage–dependent cardiomyopathySemantic proximity Read ↗

RNA Helicase DDX5 Maintains Cardiac Function by Regulating CamkIIδ Alternative SplicingSemantic proximity Read ↗

RNA binding protein IGF2BP2 expression is induced by stress in the heart and mediates dilated cardiomyopathySemantic proximity Read ↗

<i>XPO1</i> gene therapy restores cardiac function in rats with chronic induced myocardial infarctionSemantic proximity Read ↗

Echocardiography phenotyping in murine genetic reference population of BXD strains reveals significant QTLs associated with cardiac function and morphology.Semantic proximity Read ↗

Nuclear damage-induced DNA damage response coupled with IFI16-driven ECM remodeling underlies dilated cardiomyopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.