Article
Triplet repeat polymorphism in the transmembrane region of the MICA gene in celiac disease.
Tissue antigens - 1 Mar 2002
Fernandez L, Fernandez-Arquero M, Gual L, Lazaro F, Maluenda C, Polanco I, Figueredo M A, Gomez de la Concha Emilio
Abstract excerpt
Celiac disease (CD) is characterized by a striking expansion of gamma delta T cells in the intestine. These cells interact with MICA, a cell surface protein encoded by a major histocompatibility complex gene. We investigated whether MICA gene polymorphism could contribute to susceptibility to CD. DNA typing for HLA-DR, DQA1, DQB1, TNF-308, TNFa, TNFb and a triplet repeat polymorphism in the transmembrane region...
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