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Article

Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

26 Nov 2018

Abstract excerpt

A complex interplay of intrinsic factors and extrinsic signalling pathways controls both cell lineage commitment and maintenance of cell identity. Loss of defined cellular states is the cause of many different cancers, including pancreatic cancer. Recent findings suggest a clinical role for the conserved SLIT/ROBO signalling pathway in pancreatic cancer. However, whilst this pathway has been extensively studied...

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PMID: 30504829
DOI: 10.1038/s41467-018-07474-6

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