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Article

Does lung cancer mutation status and targeted therapy predict for outcomes and local control in the setting of brain metastases treated with radiation?

Neuro-oncology - 1 Jul 2015

Wang Tony J C, Saad Shumaila, Qureshi Yasir H, Jani Ashish, Nanda Tavish, Yaeh Andrew M, Rozenblat Tzlil, Sisti Michael B, Bruce Jeffrey N, McKhann Guy M, Lesser Jeraldine, Halmos Balazs, Stoopler Mark B, Lassman Andrew B, Cheng Simon K, Isaacson Steven R

Abstract excerpt

BACKGROUND: We investigated effects of genetic alterations in epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and Kirsten rat sarcoma viral oncogene homolog (KRAS) on overall survival (OS) and local control after stereotactic radiosurgery for brain metastases in non-small cell lung cancer (NSCLC). METHODS: A cohort of 89 out of 262 NSCLC patients (2003-2013) treated with gamma knife...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25910841
DOI: 10.1093/neuonc/nov043
PMCID: PMC5762012

Genes

EGFR
ALK
KRAS
EML4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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