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Article

Survival but not brain metastasis response relates to lung cancer mutation status after radiosurgery.

Journal of neuro-oncology - 1 Feb 2016

Shin Samuel M, Cooper Benjamin T, Chachoua Abraham, Butler James, Donahue Bernadine, Silverman Joshua S, Kondziolka Douglas

Abstract excerpt

We prospectively addressed whether EGFR and KRAS mutations, EML4-ALK, ROS1 and RET rearrangements, or wild-type (WT), affects radiosurgery outcomes and overall survival (OS) in non-small cell lung cancer (NSCLC) patients with brain metastases (BM). Of 326 patients with BM treated in 2012-2014 with Gamma Knife radiosurgery (GKRS), 112 NSCLC patients received GKRS as their initial intracranial treatment. OS,...

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Source

Identifiers

PMID: 26520640
DOI: 10.1007/s11060-015-1986-8

Genes

EGFR
ALK
EML4
KRAS
RET
ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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