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Article

EGFR mutant status and tyrosine-kinase inhibitors affect the GKRS outcomes for NSCLC brain metastases.

Journal of neuro-oncology - 1 Sept 2022

Liao Hung-Ruei, Chiang Chi-Lu, Shen Chia-I, Chen Ching-Jen, Yang Huai-Che, Wu Hsiu-Mei, Luo Yung-Hung, Hu Yong-Sin, Lin Chung-Jung, Chung Wen-Yuh, Shiau Cheng-Ying, Guo Wan-Yuo, Pan David Hung-Chi, Lee Cheng-Chia

Abstract excerpt

OBJECTIVE: Tyrosine kinase inhibitors (TKIs) is the first-line treatment for EGFR-positive non-small cell lung cancer (NSCLC); however, its applicability to patients with wild-type NSCLC remains an issue of contention. This study compared the effects of gamma knife radiosurgery (GKRS) alone versus combining GKRS and TKIs in treating two genetic forms of NSCLC. METHODS: This retrospective study examined 479 NSCLC...

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Identifiers

PMID: 35976545
DOI: 10.1007/s11060-022-04110-8

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