Article
Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors.
Neuropharmacology - 1 Oct 2015
Post Michael R, Limapichat Walrati, Lester Henry A, Dougherty Dennis A
Abstract excerpt
The α6-containing subtypes of the nicotinic acetylcholine receptor (nAChR) are localized to presynaptic terminals of the dopaminergic pathways of the central nervous system. Selective ligands for these nAChRs are potentially useful in both Parkinson's disease and addiction. For these and other goals, it is important to distinguish the binding behavior of agonists at the α6-β2 binding site versus other subtypes....
Topics
- Acetylcholine
- Amino Acid Sequence
- Animals
- Dose-Response Relationship, Drug
- Membrane Potentials
- Mutation
- Nicotine
- Nicotinic Agonists
- Oocytes
- Patch-Clamp Techniques
- RNA, Messenger
- Rats
- Receptors, Nicotinic
- Xenopus laevis