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Article

Long-range coupling in an allosteric receptor revealed by mutant cycle analysis.

Biophysical journal - 22 Apr 2009

Gleitsman Kristin R, Shanata Jai A P, Frazier Shawnalea J, Lester Henry A, Dougherty Dennis A

Abstract excerpt

The functional coupling of residues that are far apart in space is the quintessential property of allosteric proteins. For example, in Cys-loop receptors, the gating of an intrinsic ion channel is allosterically regulated by the binding of small molecule neurotransmitters 50-60 A from the channel gate. Some residues near the binding site must have as their primary function the communication of the binding event...

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Identifiers

PMID: 19383461
DOI: 10.1016/j.bpj.2008.12.3949
PMCID: PMC2718292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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