Article
The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H(+)-ATPase biogenesis.
PloS one - 1 Jan 2013
Kinouchi Kenichiro, Ichihara Atsuhiro, Sano Motoaki, Sun-Wada Ge-Hong, Wada Yoh, Ochi Hiroki, Fukuda Toru, Bokuda Kanako, Kurosawa Hideaki, Yoshida Naohiro, Takeda Shu, Fukuda Keiichi, Itoh Hiroshi
Abstract excerpt
The ATPase 6 accessory protein 2 (ATP6AP2)/(pro)renin receptor (PRR) is essential for the biogenesis of active vacuolar H(+)-ATPase (V-ATPase). Genetic deletion of ATP6AP2/PRR causes V-ATPase dysfunction and compromises vesicular acidification. Here, we characterized the domains of ATP6AP2/PRR involved in active V-ATPase biogenesis. Three forms of ATP6AP2/PRR were found intracellularly: full-length protein and...
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