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Article

Is renalase a novel player in catecholaminergic signaling? The mystery of the catalytic activity of an intriguing new flavoenzyme.

Current pharmaceutical design - 1 Jan 2013

Baroni Sara, Milani Mario, Pandini Vittorio, Pavesi Giulio, Horner David, Aliverti Alessandro

Abstract excerpt

Renalase is a flavoprotein recently discovered in humans, preferentially expressed in the proximal tubules of the kidney and secreted in blood and urine. It is highly conserved in vertebrates, with homologs identified in eukaryotic and prokaryotic organisms. Several genetic, epidemiological, clinical and experimental studies show that renalase plays a role in the modulation of the functions of the cardiovascular...

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PMID: 23116393
DOI: 10.2174/1381612811319140005

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