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Article

Do genetic polymorphisms modulate response rate and toxicity of Cisplatin associated with radiotherapy in laryngeal squamous cell carcinoma?: a case report.

Medicine - 1 Apr 2015

Lopes-Aguiar Leisa, Visacri Marília Berlofa, Nourani Carolina Marques Lopes, Costa Ericka Francislaine Dias, Nogueira Guilherme Augusto Silva, Lima Tathiane Regine Penna, Pincinato Eder Carvalho, Moriel Patrícia, Altemani João Maurício Carrasco, Lima Carmen Silvia Passos

Abstract excerpt

UNLABELLED: Cisplatin (CDDP) plus radiotherapy (RT) has been used to treat advanced laryngeal squamous cell carcinoma (LSCC) patients. Single nucleotide polymorphisms (SNPs) may be responsible for differences in chemo/radiosensitivity and side effects in those patients. We reported an advanced LSCC patient, who obtained durable complete response and unexpected pronounced toxicity during CDDP and RT, possibly due...

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Share to bcl-2-Associated X Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glutathione S-Transferase pi

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Share to Squamous Cell Carcinoma of Head and Neck

Source

Open in PubMed Open full text

Identifiers

PMID: 25906090
DOI: 10.1097/MD.0000000000000578
PMCID: PMC4602693

Genes

BAX
GSTP1
GSTT1
MSH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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