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Article

Genetic Variability in Cisplatin Metabolism in Kidney Injury in Patients With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiotherapy.

Head & neck - 1 Oct 2025

Costa Ericka Francislaine Dias, Ferreira Ana Maria Castro, Mazzali Marilda, Lourenço Gustavo Jacob, Lima Carmen Silvia Passos

Abstract excerpt

BACKGROUND: This study investigated the roles of single nucleotide variants (SNVs) in genes of CDDP metabolism and their association with kidney dysfunction in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: A total of 109 patients with locally advanced HNSCC, treated with CDDP, had renal function evaluated by serum creatinine level and CKD-EPI formula, and underwent genotyping by polymerase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40342074
DOI: 10.1002/hed.28179
PMCID: PMC12434574

Genes

ERCC1
GSTP1
GSTT1
MLH1
MSH3
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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