Article
Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis: the impact of genome-wide association studies identified disease risk loci.
Pharmacogenomics - 1 Nov 2017
Kulakova Olga, Bashinskaya Vitalina, Kiselev Ivan, Baulina Natalia, Tsareva Ekaterina, Nikolaev Ruslan, Kozin Maxim, Shchur Sergey, Favorov Alexander, Boyko Alexey, Favorova Olga
Abstract excerpt
AIM: Association analysis of genome-wide association studies (GWAS) identified multiple sclerosis (MS) risk genetic variants with glatiramer acetate (GA) treatment efficacy. PATIENTS & METHODS: SNPs in 17 GWAS-identified immune response loci were analyzed in 296 Russian MS patients as possible markers of optimal GA treatment response for at least 2 years. RESULTS: Alleles/genotypes of EOMES, CLEC16A, IL22RA2,...
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