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Article

Two-sided block of a dual-topology F- channel.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015

Turman Daniel L, Nathanson Jacob T, Stockbridge Randy B, Street Timothy O, Miller Christopher

Abstract excerpt

The Fluc family is a set of small membrane proteins forming F(-)-specific electrodiffusive ion channels that rescue microorganisms from F(-) toxicity during exposure to weakly acidic environments. The functional channel is built as a dual-topology homodimer with twofold symmetry parallel to the membrane plane. Fluc channels are blocked by nanomolar-affinity fibronectin-domain monobodies originally selected from...

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Identifiers

PMID: 25902543
DOI: 10.1073/pnas.1505301112
PMCID: PMC4426430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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