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Article

Identification and genetic manipulation of human and mouse oesophageal stem cells

20 Apr 2015

Abstract excerpt

OBJECTIVE: Human oesophageal stem cell research is hampered by the lack of an optimal assay system to study self-renewal and differentiation. We aimed to identify and characterise human and mouse oesophageal stem/progenitor cells by establishing 3-dimensional organotypic sphere culture systems for both species. DESIGN: Primary oesophageal epithelial cells were freshly isolated and fluorescence-activated cell...

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PMID: 25897018
DOI: 10.1136/gutjnl-2014-308491

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