Article
Mitochondrial DNA Content as Risk Factor for Bladder Cancer and Its Association with Mitochondrial DNA Polymorphisms.
Cancer prevention research (Philadelphia, Pa.) - 1 Jul 2015
Williams Stephen B, Ye Yuanqing, Huang Maosheng, Chang David W, Kamat Ashish M, Pu Xia, Dinney Colin P, Wu Xifeng
Abstract excerpt
Mitochondrial DNA (mtDNA) content has been shown to be associated with cancer susceptibility. We identified 926 bladder cancer patients and compared these with 926 healthy controls frequency matched on age, gender, and ethnicity. Patients diagnosed with bladder cancer had significantly decreased mtDNA content when compared with control subjects (median, 0.98 vs. 1.04, P < 0.001). Low mtDNA content (i.e., less...
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