MYC variant at 8q24 increases susceptibility to urinary bladder cancer: a meta-analysis of 53,957 individuals.

doi:10.1080/17410541.2025.2592528

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MYC variant at 8q24 increases susceptibility to urinary bladder cancer: a meta-analysis of 53,957 individuals.

Personalized medicine - 1 Dec 2025

de Moraes Francisco Cezar Aquino, Rego Luis Henrique Rios Moreira, Morbach Victória, de Lima Micael Porto Portela, Burbano Rommel Mario Rodriguez

Abstract excerpt

BACKGROUND: Urinary bladder cancer (UBC), the tenth most common globally with a male predominance, has its risk factors like smoking and single nucleotide polymorphisms (SNPs), yet the MYC gene's role, especially the rs9642880 GT/TT polymorphism on chromosome 8q24.21, in cancer susceptibility is underexplored. METHODS: We searched in Medline, Scopus and Web of Science databases for relevant studies. Odds ratios...

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PMID: 41268746
DOI: 10.1080/17410541.2025.2592528

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