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Article

Intermittent induction of HIF-1α produces lasting effects on malignant progression independent of its continued expression.

PloS one - 1 Jan 2015

Choi Hyunsung, Gillespie David L, Berg Shauna, Rice Christopher, Couldwell Sandrine, Gu Jie, Colman Howard, Jensen Randy L, Huang L Eric

Abstract excerpt

Dysregulation of hypoxia-inducible transcription factors HIF-1α and HIF-2α correlates with poor prognosis in human cancers; yet, divergent and sometimes opposing activities of these factors in cancer biology have been observed. Adding to this complexity is that HIF-1α apparently possesses tumor-suppressing activities, as indicated by the loss-of-function mutations or even homozygous deletion of HIF1A in certain...

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Identifiers

PMID: 25893706
DOI: 10.1371/journal.pone.0125125
PMCID: PMC4404255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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