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Article

The selective hypoxia inducible factor-1 inhibitor PX-478 providesin vivoradiosensitization through tumor stromal effects

1 Apr 2009

Abstract excerpt

Hypoxia inducible factor-1 (HIF-1) promotes tumor cell adaptation to microenvironmental stress. HIF-1 is up-regulated in irradiated tumors and serves as a promising target for radiosensitization. We initially confirmed that the orally bioavailable HIF-1 inhibitor PX-478 reduces HIF-1 protein levels and signaling in vitro in a dose-dependent manner and provides direct radiosensitization of hypoxic cancer cells in...

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PMID: 19372568
DOI: 10.1158/1535-7163.mct-08-0981

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