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Article

Expression of hypoxia-inducible factor 1? in brain tumors

1 Jun 2000

Abstract excerpt

BACKGROUND: Hypoxia inducible factor-1 (HIF-1) plays a critical role in angiogenesis during vascular development. The authors tested the hypothesis that HIF-1 expression correlates with progression and angiogenesis in brain tumors. METHODS: The authors investigated the expression of the HIF-1alpha and HIF-1beta subunits in human glioma cell lines and brain tumor tissues using Western blot analysis and...

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PMID: 10861440
DOI: 10.1002/1097-0142(20000601)88:11<2606::aid-cncr25>3.0.co;2-w

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