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Article

Metabolic dysfunction in lymphocytes promotes postoperative morbidity.

Clinical science (London, England : 1979) - 1 Sept 2015

Edwards Mark R, Sultan Pervez, del Arroyo Ana Gutierrez, Whittle John, Karmali Shamir N, Moonesinghe S Ramani, Haddad Fares S, Mythen Michael G, Singer Mervyn, Ackland Gareth L

Abstract excerpt

Perioperative lymphopenia has been linked with an increased risk of postoperative infectious complications, but the mechanisms remain unclear. We tested the hypothesis that bioenergetic dysfunction is an important mechanism underlying lymphopenia, impaired functionality and infectious complications. In two cohorts of patients (61-82 years old) undergoing orthopaedic joint replacement (n=417 and 328,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25891048
DOI: 10.1042/CS20150024

Genes

NLRP1
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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