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Inhibition of highly pathogenic PRRSV replication in MARC-145 cells by artificial microRNAs

1 Nov 2011

Abstract excerpt

BACKGROUND: Highly pathogenic porcine reproductive and respiratory syndrome (HP-PRRS) has caused large economic losses in swine industry in recent years. However, current antiviral strategy could not effectively prevent and control this disease. In this research, five artificial microRNAs (amiRNAs) respectively targeted towards ORF5 (amirGP5-243, -370) and ORF6 (amirM-82, -217,-263) were designed and incorporated...

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PMID: 22040357
DOI: 10.1186/1743-422x-8-491

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