Article
Polymorphisms in chloroquine resistance-associated genes in Plasmodium vivax in Ethiopia.
Malaria journal - 16 Apr 2015
Golassa Lemu, Erko Berhanu, Baliraine Frederick N, Aseffa Abraham, Swedberg Göte
Abstract excerpt
BACKGROUND: Evidence for decreasing chloroquine (CQ) efficacy against Plasmodium vivax has been reported from many endemic countries in the world. In Ethiopia, P. vivax accounts for 40% of all malaria cases and CQ is the first-line drug for vivax malaria. Mutations in multidrug resistance 1 (pvmdr-1) and K10 insertion in the pvcrt-o genes have been identified as possible molecular markers of CQ-resistance (CQR)...
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