Article
Cross-laboratory validation of the OncoScan® FFPE Assay, a multiplex tool for whole genome tumour profiling.
BMC medical genomics - 18 Feb 2015
Foster Joseph M, Oumie Assa, Togneri Fiona S, Vasques Fabiana Ramos, Hau Debra, Taylor Morag, Tinkler-Hundal Emma, Southward Katie, Medlow Paul, McGreeghan-Crosby Keith, Halfpenny Iris, McMullan Dominic J, Quirke Phil, Keating Katherine E, Griffiths Mike, Spink Karen G, Brew Fiona
Abstract excerpt
BACKGROUND: Adoption of new technology in both basic research and clinical settings requires rigorous validation of analytical performance. The OncoScan® FFPE Assay is a multiplexing tool that offers genome-wide copy number and loss of heterozygosity detection, as well as identification of frequently tested somatic mutations. METHODS: In this study, 162 formalin fixed paraffin embedded samples, representing six...
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