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Article

A molecular switch sensor for detection of PRSS1 genotype based on site-specific DNA cleavage of restriction endonuclease.

Annals of clinical and laboratory science - 1 Jan 2015

Liu Qicai, Gao Feng, Weng Shaohuang, Peng Huaping, Lin Liqing, Zhao Chengfei, Lin Xinhua

Abstract excerpt

BACKGROUND: PRSS1 mutations or polymorphism in the peripheral blood of patients can be used as susceptible molecular markers to pancreatic cancer. A sensor for selective electrochemical detection of PRSS1 genotypes was developed based on site-specific DNA cleavage of restriction endonuclease EcoRI. METHODS: A mercapto-modified hairpin probe was immobilized on a gold electrode. The probe's neck can be cleaved by...

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PMID: 25887864

Genes

PRSS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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