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Sensitive electrochemical detection of polymorphisms in IL6 and TGFβ1 genes from ovarian cancer DNA patients using EcoRI and DNA hairpin-modified gold electrodes.

Mikrochimica acta - 7 Dec 2022

Meftah Maroua, Habel Azza, Baachaoui Sabrine, Yaacoubi-Loueslati Basma, Raouafi Noureddine

Abstract excerpt

Two electrochemical bioplatforms were prepared based on thiolated hairpin DNA probes tethered to AuNP-modified screen-printed electrodes to detect T > G and T > C polymorphisms, namely rs1880269 and rs1800469, present the interleukin-6 (IL6) and transforming growth factor β1 (TGFβ1) genes. The electrochemical readout was ensured by the detection of the double-stranded DNA using methylene blue as a redox probe...

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PMID: 36479645
DOI: 10.1007/s00604-022-05595-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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