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Article

Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation.

Communications biology - 22 Jul 2021

Dhar Payal, Basher Fahmin, Ji Zhe, Huang Lei, Qin Si, Wainwright Derek A, Robinson Jerid, Hagler Shaye, Zhou Jing, MacKay Sean, Wu Jennifer D

Abstract excerpt

Natural Killer (NK) cell dysfunction is associated with poorer clinical outcome in cancer patients. What regulates NK cell dysfunction in tumor microenvironment is not well understood. Here, we demonstrate that the human tumor-derived NKG2D ligand soluble MIC (sMIC) reprograms NK cell to secrete pro-tumorigenic cytokines with diminished cytotoxicity and polyfunctional potential. Antibody clearing sMIC restores NK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34294876
DOI: 10.1038/s42003-021-02440-3
PMCID: PMC8298432

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