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Article

An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2015

Cardnell Robert J G, Behrens Carmen, Diao Lixia, Fan YouHong, Tang Ximing, Tong Pan, Minna John D, Mills Gordon B, Heymach John V, Wistuba Ignacio I, Wang Jing, Byers Lauren A

Abstract excerpt

PURPOSE: Thyroid transcription factor-1 (TTF1) immunohistochemistry (IHC) is used clinically to differentiate primary lung adenocarcinomas (LUAD) from squamous lung cancers and metastatic adenocarcinomas from other primary sites. However, a subset of LUAD (15%-20%) does not express TTF1, and TTF1-negative patients have worse clinical outcomes. As there are no established targeted agents with activity in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25878335
DOI: 10.1158/1078-0432.CCR-14-3286
PMCID: PMC4526428

Genes

TTF1
BRAF
KEAP1
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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