Article
Thyroid transcription factor 1 (TTF-1) negativity as a predictor of unfavorable response to EGFR-TKI therapy in advanced lung adenocarcinoma patients with EGFR mutations.
Thoracic cancer - 1 Oct 2023
Ding Xiaosheng, Shi Weiwei, Han Bingxuan, Chen Hanxiao, Li Jia, An Juan, Zhou Lili, Xu Weiran, Shi Hui, Zheng Xixi, Hua Yichun, Li Xiaoyan
Abstract excerpt
BACKGROUND: The absence of thyroid transcription factor 1 (TTF-1) is associated with a lower frequency of epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma (LUAD). The aim of this study was to assess the impact of TTF-1 expression on the clinical response to EGFR-tyrosine kinase inhibitor (TKI) treatment in patients with advanced LUAD. METHODS: The data of patients with advanced LUAD who...
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