Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-145 Contributes to Hypertrophic Scarring of the Skin by Inducing Myofibroblast Activity.

Molecular medicine (Cambridge, Mass.) - 9 Apr 2015

Gras Christiane, Ratuszny Dominica, Hadamitzky Catarina, Zhang Haijiao, Blasczyk Rainer, Figueiredo Constança

Abstract excerpt

Hyperthrophic scarring of the skin is caused by excessive activity of skin myofibroblasts after wound healing and often leads to functional and/or aesthetic disturbance with significant impairment of patient quality of life. MicroRNA (miRNA) gene therapies have recently been proposed for complex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cell Movement
Share to Collagen Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Factor 4

Share to Kruppel-Like Transcription Factors

Share to Myofibroblasts

Share to RNA Interference

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 25876136
DOI: 10.2119/molmed.2014.00172
PMCID: PMC4503650

Genes

KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25876136-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-145 Contributes to Hypertrophic Scarring of the Skin by Inducing Myofibroblast Activity.PMID 25876136Read ↗

MicroRNA‐145‐5p regulates fibrotic features of recessive dystrophic epidermolysis bullosa skin fibroblastsSemantic proximity Read ↗

A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.Semantic proximity Read ↗

MicroRNA-185 regulates transforming growth factor-β1 and collagen-1 in hypertrophic scar fibroblastsSemantic proximity Read ↗

MicroRNA-146a modulates TGF-β1-induced phenotypic differentiation in human dermal fibroblasts by targeting SMAD4Semantic proximity Read ↗

Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop.Semantic proximity Read ↗

Protective role for miR-9-5p in the fibrogenic transformation of human dermal fibroblastsSemantic proximity Read ↗

Mechanical stretch suppresses microRNA-145 expression by activating extracellular signal-regulated kinase 1/2 and upregulating angiotensin-converting enzyme to alter vascular smooth muscle cell phenotype.Semantic proximity Read ↗

Wnt/β-catenin pathway forms a negative feedback loop during TGF-β1 induced human normal skin fibroblast-to-myofibroblast transition.Semantic proximity Read ↗

Ski diminishes TGF-β1-induced myofibroblast phenotype via up-regulating Meox2 expression.Semantic proximity Read ↗

MicroRNA-98 inhibits the cell proliferation of human hypertrophic scar fibroblasts via targeting Col1A1Semantic proximity Read ↗

A Role for miR-145 in Pulmonary Arterial HypertensionSemantic proximity Read ↗

Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.