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Article

Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).

The Journal of biological chemistry - 6 Jan 2012

Martinez-Sanchez Aida, Dudek Katarzyna A, Murphy Chris L

Abstract excerpt

Articular cartilage enables weight bearing and near friction-free movement in the joints. Critical to its function is the production of a specialized, mechanocompetent extracellular matrix controlled by master regulator transcription factor SOX9. Mutations in SOX9 cause campomelic dysplasia, a ha...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22102413
DOI: 10.1074/jbc.M111.302430
PMCID: PMC3256897

Genes

SOX9
MMP13
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22102413-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).PMID 22102413Read ↗

High through-put identification of miR-145 targets in human articular chondrocytesSemantic proximity Read ↗

miR-1247 functions by targeting cartilage transcription factor SOX9.Semantic proximity Read ↗

The Epigenetic Regulation of SOX9 by miR‐145 in Human ChondrosarcomaSemantic proximity Read ↗

Zinc‐finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repairSemantic proximity Read ↗

Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes.Semantic proximity Read ↗

Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasisSemantic proximity Read ↗

Aberrant miR‐145–5p/β‐catenin signal impairs osteocyte function in adolescent idiopathic scoliosisSemantic proximity Read ↗

MiR-146b is down-regulated during the chondrogenic differentiation of human bone marrow derived skeletal stem cells and up-regulated in osteoarthritisSemantic proximity Read ↗

L-Sox5 and Sox6 Proteins Enhance Chondrogenic miR-140 MicroRNA Expression by Strengthening Dimeric Sox9 ActivitySemantic proximity Read ↗

SOX9 and the many facets of its regulation in the chondrocyte lineageSemantic proximity Read ↗

Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5pSemantic proximity Read ↗

Highly efficient CRISPR-Cas9-mediated editing identifies novel mechanosensitive microRNA-140 targets in primary human articular chondrocytesSemantic proximity Read ↗

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