Article
Structural determinants of phenotypic diversity and replication rate of human prions.
PLoS pathogens - 1 Apr 2015
Safar Jiri G, Xiao Xiangzhu, Kabir Mohammad E, Chen Shugui, Kim Chae, Haldiman Tracy, Cohen Yvonne, Chen Wei, Cohen Mark L, Surewicz Witold K
Abstract excerpt
The infectious pathogen responsible for prion diseases is the misfolded, aggregated form of the prion protein, PrPSc. In contrast to recent progress in studies of laboratory rodent-adapted prions, current understanding of the molecular basis of human prion diseases and, especially, their vast phenotypic diversity is very limited. Here, we have purified proteinase resistant PrPSc aggregates from two major...
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