Article
Alteration of major vault protein in human glioblastoma and its relation with EGFR and PTEN status.
Neuroscience - 25 Jun 2015
Navarro L, Gil-Benso R, Megías J, Muñoz-Hidalgo L, San-Miguel T, Callaghan R C, González-Darder J M, López-Ginés C, Cerdá-Nicolás M J
Abstract excerpt
Glioblastoma (GBM) is the most frequent and malignant primary brain tumor. Conventional therapy of surgical removal, radiation and chemotherapy is largely palliative. Major vault protein (MVP), the main component of the vault organelle has been associated with multidrug resistance by reducing cellular accumulation of chemotherapeutic agents. With regard to cancer, MVP has been shown to be overexpressed in drug...
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