Article
A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.
The Journal of biological chemistry - 22 May 2015
Koban Florian, El-Kasaby Ali, Häusler Cornelia, Stockner Thomas, Simbrunner Benedikt M, Sitte Harald H, Freissmuth Michael, Sucic Sonja
Abstract excerpt
The folding trajectory of solute carrier 6 (SLC6) family members is of interest because point mutations result in misfolding and thus cause clinically relevant phenotypes in people. Here we examined the contribution of the C terminus in supporting folding of the serotonin transporter (SERT; SLC6A4). Our working hypothesis posited that the amphipathic nature of the C-terminal α-helix (Thr(603)-Thr(613)) was...
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